Cells house organelles enclosed by membranes, which partition cellular components. Recent captivating research suggests an additional means of intracellular compartmentalization and organization, namely liquid-liquid phase separation of proteins and nucleic acids, forming noncanonical membrane-less organelles. These dynamic biomolecular condensates, resembling liquids, may undergo undesirable irreversible phase transitions, leading to gel-like or solid-like amyloid aggregates. Such transformations are linked to various severe human diseases.
In a brand-new paper, Ashish Joshi and colleagues from the team of Samrat Mukhopadhyay at IISER Mohali take a close look at the molecular events during phase separation of the prion-like domain of the FUS protein with single-molecule fluorescence methods.
Our speaker, Professor Samrat Mukhopadhyay, will present ‘A deep dive into biomolecular condensates using single-molecule FRET’. The webinar is on Thursday 11 January at 14:00 GMT, 15:00 CET and 19:30 IST.
If you want to learn what single molecule fluorescence microscopy techniques revealed about the complex behavior of the FUS low-complexity domain during liquid-liquid phase separation, register for our upcoming webinar featuring Prof. Samrat Mukhopadhyay, co-hosted with FocalPlane.